NeuroMab™ Anti-ACT Antibody(NRZP-1222-ZP780)

[CAT#: NRZP-1222-ZP780]

Host Species:: Mouse

Species Reactivity:: Human

Applications:: Neut; Inhib

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry

Product Overview

Description

Integrins are ubiquitous cell-surface heterodimers that are exploited by pathogens and toxins, including leukotoxins that target β 2 integrins on phagocytes. The Bordetella adenylate cyclase toxin (ACT) uses the α M β 2 integrin as a receptor. The neutralizing antibody epitopes map to ACT residues involved in α M binding, providing the basis for antibody-mediated attachment inhibition.