Product Overview

Description

The isolated monoclonal antibody binds to the epitope of a human RAGE molecule. It's capable of being used in the treatment and diagnosis of Alzheimer's disease (AD), central nervous system cell degeneration, learning and memory impairment, abnormal transport of amyloid β, and other neurological inflammatory symptoms associated with a receptor for advanced-glycation-end-products (RAGE).

Immunogen

C2 domain

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; FC; IHC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

RAGE

Official Name

AGER

Full Name

advanced glycosylation end product-specific receptor

Alternative Names

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor; and besides AGE; interacts with other molecules implicated in homeostasis; development; and inflammation; and certain diseases; such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms; as well as non-protein-coding variants; have been described for this gene.