Name: iNeuMab™ Anti-Nav1.4 sodium channel BBB Shuttle Antibody (NRZP-0423-ZP280)
SKU: NRZP-0423-ZP280
Rating: 5 (1 reviews)

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN4A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 269-386 (Repeat I external pore between S5 and S6) of rat Nav1.4 (also known as Voltage-gated sodium channel subunit alpha Nav1.4, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Scn4a, SkM1 and Mu-1, accession number P15390)
Mouse: 96% identity (113/118 amino acids identical)
Human: 85% identity (106/124 amino acids identical)
<60% identity with Nav1.2, Nav1.3 and other Nav1 channels

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat

Clonality

Monoclonal

Isotype

IgG2a

Research Areas

Na+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SCN4A

Official Name

SCN4A

Full Name

Nav1.4 Na+ channel

Alternative Names

Sodium Voltage-Gated Channel Alpha Subunit 4; Sodium Channel; Voltage-Gated; Type IV; Alpha Subunit; Sodium Channel Protein Skeletal Muscle Subunit Alpha; Voltage-Gated Sodium Channel Subunit Alpha Nav1.4; Sodium Channel Protein Type IV Subunit Alpha; SkM1; Skeletal Muscle Voltage-Dependent Sodium Channel Type IV Alpha Subunit; Sodium Channel; Voltage Gated; Type IV Alpha Subunit; Skeletal Muscle Sodium Channel Alpha Subunit; Sodium Channel Protein Type 4 Subunit Alpha;