NeuroMab™ Anti-ADAM17 BBB Shuttle Antibody(NRZP-1022-ZP3626)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

Inhib; In Vitro

Relevant Diseases

Multiple Sclerosis; Tumor

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

ADAM17

Official Name

ADAM17

Full Name

ADAM Metallopeptidase Domain 17

Alternative Names

ADAM Metallopeptidase Domain 17; Tumor Necrosis Factor; Alpha; Converting Enzyme; Snake Venom-Like Protease; TNF-Alpha Convertase; TACE; CSVP; Disintegrin And Metalloproteinase Domain-Containing Protein 17; ADAM Metallopeptidase Domain 18;

Product Pictures

FuncS

Figure 1A: Comparison of maximal inhibition of Nluc fusion protein AREG shedding by ml022C3 and hzl022C3.

A: Means are significantly different :Unpaired t test (a<0.05) : p=0.0005)

FuncS

Figure 2 B: Comparing ml022C3 and hzl022C3 for maximal inhibition of Nluc fusion protein shedding AREG (A: means significantly different: unpaired t-test (a<0.05): p=0.0005), TGFa (B: means significantly different : unpaired t-test (a<0.05): p=0.0003) and HB-EGF (C: means significantly different: unpaired t-test (a<0.05): p=0.0069) from stably transfected cell line A431 , the level of untreated cells expressed as a percentage of baseline shedding.

B: Means are significantly different :Unpaired t test (a<0.05) : p=0.0003) and HB-EGF

FuncS

Figure 3C: Comparison of maximal inhibition of Nluc fusion protein shedding by ml022C3 and hzl022C3 AREG (A: means significantly different: unpaired t-test (a<0.05): p=0.0005), TGFa (B: means significantly different: Unpaired t-test (a<0.05): p=0.0003) and HB-EGF (C: means significantly different: unpaired t-test (a<0.05): p=0.0069) from stably transfected cell line A431, Levels of untreated cells expressed as percentage of baseline shedding.

C: Means are significantly different :Unpaired t test (a<0.05) : p=0.0069) from stably transfected cell line A431 expressed as a percentage of baseline shedding levels of untreated cells.