NeuroMab™ Anti-Artemin Antibody(NRP-0422-P533)

Product Overview

Description

The monoclonal antibody NRP-0422-P533 clone specifically binds to E. coli rat Neublastin protein. The NR3577P monoclonal antibody was also found to bind to human neublastin. The antibody can be used for detecting the presence or amount of endogenous and/or exogenous neublastin in a sample and in methods of antagonizing neublastin bioactivity.

Immunogen

human neublastin (hNBN104)-hIgG1 Fc recombinant protein

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; ELISA; Block; Inhib; In Vitro

Relevant Diseases

Alzheimer's Disease; Parkinson's Disease; Huntington's Disease; Multiple Sclerosis

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Artemin

Official Name

artemin

Full Name

ARTN

Alternative Names

ENOVIN; Neublastin; EVN; Artemin; Enovin; NBN; ARTN;

Gene ID

9048(Human);11876(Mouse)

Uniprot ID

Q5T4W7(Human);Q9Z0L2(Mouse)

Product Pictures

Inhib

Figure 1 is a scatter plot depicting the ability of anti-hNBN mAbs to inhibit NBN-mediated c-RET phosphorylation in mouse cells.

Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).

Publications