NeuroMab™ Anti-Galanin BBB Shuttle Antibody(NRZP-1022-ZP3373)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a/κ

Applications

WB; ELISA; FC; Inhib; Block; Cyt; In Vitro

Relevant Diseases

Alzheimer's Disease; Epilepsy; Depression

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Galanin

Official Name

GAL

Full Name

Galanin

Alternative Names

GAL; GAL-GMAP; GALN; GLNN; GMAP; ETL8; galanin and GMAP prepropeptide

Product Pictures

FuncS

Figure 1 shows the results of the GALR2 filtration assay.

Membrane preparations from A9 cells engineered to overexpress GALR2 were incubated with 125I-labeled human galanin and mouse anti-galanin hybridoma supernatants and harvested onto GF/B Unifilter plates. Twenty-one hybridomas were able to inhibit the binding of human galanin to GALR2.