NeuroMab™ Anti-GARP BBB Shuttle Antibody(NRZP-1022-ZP3030)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; Inhib; Block; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

GARP

Official Name

LRRC32

Full Name

Leucine Rich Repeat Containing 32

Alternative Names

Leucine Rich Repeat Containing 32 ; Glycoprotein A Repetitions Predominant ; Transforming Growth Factor Beta Activator LRRC3; Leucine-Rich Repeat-Containing Protein 3; D11S833E ; Garpin ; GARP ; LRRC32

Product Pictures

Inhib

Figure 1 Inhibition of human Treg function by anti-hGARP in vivo.

Inhib

Figure 2 MHGARP8 inhibits production of active TGF-β by human Treg clones.

FCM

Figure 3 Insufficient presentation of hTGF-β1 on the cell surface for binding by MHGARP8. 293T cells were transfected as indicated below, stained with anti-hLAP antibody or MGARP8, and analyzed by flow cytometry.

FuncS

Figure 4 MHGARP8 inhibits Treg function in vivo. On day 0, designated groups of NSG mice received intravenous injections. Human PBMC were injected with or without human Tregs.