NeuroMab™ Anti-PSK9 Antibody(NRP-0422-P1529)

Product Overview

Description

The antibody can be used for treating diseases and disorders which are treatable and/or improved by antagonizing PCSK9, e.g., by blocking the interaction of PCSK9 with the LDL receptor (LDLR).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

Block; Inhib; In Vivo; In Vitro

Relevant Diseases

Alzheimer's Disease; Stroke; Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

PSK9

Official Name

PCSK9

Full Name

Proprotein Convertase Subtilisin/Kexin Type 9

Alternative Names

Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9; NARC-1; NARC1; PC9; Convertase Subtilisin/Kexin Type 9 Preproprotein; Hypercholesterolemia; Autosomal Dominant 3; Neural Apoptosis Regulated Convertase 1; Neural Apoptosis-Regulated Convertase 1;

Gene ID

100102(Human)

Uniprot ID

Q80W65(Human)

Product Pictures

FuncS

Figure 1 shows the serum concentrations of anti-PCSK9 antibodies measured in mice expressing only mouse PCSK9 (i.e., not human PCSK9) at different time points after subcutaneous administration of anti-PCSK9 antibodies at a dose of 1 mg/kg.

FuncS

Figure 2 shows the serum concentrations of anti-PCSK9 antibodies measured in mice expressing human PCSK9 (instead of mouse PCSK9) at different time points after subcutaneous administration of anti-PCSK9 antibodies at a dose of 1 mg/kg.

FuncS

Figure 3 shows sensorgrams from surface plasmon resonance binding experiments in which an anti-PCSK9 antibody was allowed to bind human PCSK9 antigen at neutral pH (pH 7.4) and then transferred to cells with different pH values (7.4, 7.2, 6.0, and 5.75). ) buffer for the dissociation phase.

Publications