NeuroMab™ Anti-TNFα Antibody(NRP-0422-P782)

Product Overview

Description

The antibody is specific for human tumor necrosis factor-α (TNFα) and is useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Chimeric

Applications

ELISA; Neut; Block; Inhib; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

TNFα

Official Name

TNF-α

Full Name

TNF-alpha

Alternative Names

TNF; DIF; TNF-alpha; TNFA; TNFSF2; Tumour necrosis factor; TNF-α; tumor necrosis factor; TNLG1F; Tumor necrosis factor alpha

Gene ID

7124(Human); 21926(Mouse)

Uniprot ID

P01375(Human); P06804(Mouse)

Product Pictures

ELISA

Figure 1 is a graph showing the dose-dependent binding of mouse mAb A2 to human TNF[alpha].

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Figure 2 is a graph showing the neutralizing effect of murine A2 on TNF cytotoxicity in vitro.

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Figure 3 shows that mAb A2 inhibits or neutralizes TNF produced by chimpanzee monocytes and rhTNF[alpha].

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Figure 4 is a graph showing the neutralizing effect of chimeric A2 on TNF cytotoxicity.

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Figure 5 shows the results of a cross-blocking epitope ELISA for mouse A2 (mA2).

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Figure 6 is a graph showing the in vitro neutralization of TNF-induced ELAM-1 expression by chimeric A2. The control is a chimeric mouse/human IgG1 anti-CD4 antibody.

Publications