Name: iNeuMab™ Anti-Kv6.4 potassium channel BBB Shuttle Antibody (NRZP-0423-ZP229)
SKU: NRZP-0423-ZP229
Rating: 5 (1 reviews)

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNG4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-219 (cytoplasmic N-terminus) of mouse Kv6.4 (also known as Voltagegated potassium channel subunit Kv6.4, Potassium voltage-gated channel subfamily G member 4, Kcng4, KCNG3 and rCG_51585, accession number Q80XM3)
Rat: 95% identity (207/219 amino acids identical)
Human: 72% identity (161/225 amino acids identical)
<50% identity with Kv6.1/KCNG1 and other potassium channel subunits

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNG4

Official Name

KCNG4

Full Name

Kv6.4 K+ channel

Alternative Names

Potassium Voltage-Gated Channel Modifier Subfamily G Member 4; Potassium Voltage-Gated Channel; Subfamily G; Member 4; Voltage-Gated Potassium Channel Subunit Kv6.4; Potassium Channel; Voltage Gated Modifier Subfamily G; Member 4; Potassium Voltage-Gated Channel Subfamily G Member 4; Voltage-Gated Potassium Channel Kv6.3; KV6.3; KV6.4; KCNG3;