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Creative Biolabs
Product

NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody,Clone NR1709P

[CAT#: NRZP-1022-ZP4051]

Host Species:
Humanized
Species Reactivity:
Human
Applications:
In Vitro

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Clone Number

NR1709P

Applications

In Vitro

Relevant Diseases

Parkinson's Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

AlphaSynuclein

Official Name

SNCA

Full Name

Alpha-synuclein

Alternative Names

SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha
Product Pictures

Figure 2 shows the results of passive immunotherapy using 5C1 for speed and error in the round beam test.

ELISA

Figure 3 shows the results of an ELISA assay testing the affinity of different humanized 5C1 antibodies.

WB

Figure 4 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of α-synuclein bound by the 9E4 antibody.

The upper part of the panel shows the protein of full-length α-synuclein (wild-type or individual point mutations of residues 118-126, as indicated) stained with the 9E4 antibody (left panel) or the control antibody 1H7 (right panel). blot. The lower part of the figure shows the epitope of α-synuclein bound by the 9E4 antibody.

WB

Figure 5 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of [alpha]-synuclein to which the 5C1 antibody binds.

The upper part of the panel shows full-length α-synuclein (wild-type or a single point mutation in residues 118-126, as indicated) stained with the 5C1 antibody (left panel) or the control antibody 1H7 (right panel). Western blot. The lower part of the figure shows the epitope of α-synuclein bound by the 5C1 antibody.

WB

Figure 6 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of α-synuclein bound by the 5D12 antibody.

Figure 7 depicts a ball-and-stick model of the amino acids of α-synuclein near the binding site of the 9E4, 5C1 and 5D12 antibodies.

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For Research Use Only. Not For Clinical Use.
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