Tau Phosphorylation Assay Service

The tau phosphorylation assay is an important tool for studying tau diseases such as Alzheimer's disease (AD). Tau has up to 85 phosphorylation sites. Accurate detection of these sites is central to the analysis of disease mechanisms and the development of targeted therapies. For further information regarding the products and services provided, project-specific consultation, and pricing, please submit an inquiry here.

Why Focus on Tau Phosphorylation?

Putative phosphorylation sites on tau protein and epitopes specific for major tau antibodies. (Šimić, et al., 2016)

Tau protein is a key protein for neuronal microtubule stability, and the dynamic balance of its phosphorylation state is critical for neuronal function. Abnormal phosphorylation can cause tau to dissociate from microtubules and form neurofibrillary tangles (NFTs), which are the hallmark pathological features of neurodegenerative diseases such as AD and Pick's disease. Tau has up to 85 phosphorylation sites (such as Ser202, Thr231, Ser396, etc.), and phosphorylation at different sites is specific to different stages of the disease.

Advantages of Our Service

High Throughput Screening

Highly specific detection: Uses double antibody sandwich ELISA technology, supporting the detection of key sites such as pS396, p-TAU181 (Thr181), Ser404, Ser202/Thr205, etc.
Broad applicability: It can analyze phosphorylated tau levels in a variety of samples such as cerebrospinal fluid, cell culture medium, and tissue lysate.

Robust technology and reliable data

Standardized procedure: Based on international experimental methods (such as immunoblotting, immunofluorescence), combined with strict quality control (sensitivity, batch consistency, etc.) to ensure reproducibility of results.
Dynamic monitoring: Supports simultaneous analysis of phosphorylated and total tau protein, revealing the relationship between phosphorylation levels and pathological processes.

Support cutting-edge research and transforming applications

Mechanism research: Analyzing the regulation of tau phosphorylation by kinases such as GSK-3β and CDK5 and exploring targets for drug intervention.
Biomarker exploration: Providing data support for early diagnosis of AD, combining the potential of cerebrospinal fluid and blood testing.

Fig 1: Measuring tau phosphorylation in CSF from Alzheimer's Disease patients. Fig.1 Measurement of tau phosphorylation in cerebrospinal fluid (CSF) of AD patients.^{2, 3}

Why Choose Us?

Accuracy at the level of scientific research: strictly distinguish pathological from physiological phosphorylation to avoid non-specific signal interference.
One-stop support: From experimental design to data analysis, we provide complete technical consulting and literature support.
Commitment to compliance: Services will be used only for scientific research and in accordance with ethical and industry standards.

At Creative Biolabs, we offer expert tau phosphorylation measurement services to accurately analyze tau phosphorylation and support neurodegenerative disease research. Contact us today to discuss a customized detection solution.

References

Šimić, Goran, et al. "Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies." Biomolecules 6.1 (2016): 6.
Gobom, Johan, et al. "Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease continuum." Molecular neurodegeneration 17.1 (2022): 81.
Distributed under Open Access license CC BY 4.0, without modification.

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