CNS-related Cellular Kinase Assay Service

Our CNS-related cellular kinase assay service offers precise, high-throughput analysis of intracellular and receptor tyrosine kinases (RTKs). We deliver accurate measurements of kinase activity, compound binding, target protein affinity, and selectivity, empowering your research into complex central nervous system (CNS) signaling pathways and disease mechanisms. With exceptional sensitivity and specificity, our platform is ideal for studies ranging from basic research to drug discovery. For further information regarding the products and services provided, project-specific consultation, and pricing, please submit an inquiry here.

CNS-related Cellular Kinases

CNS-related kinases serve as pivotal regulators of neuronal development, synaptic plasticity, and energy metabolism, making them essential targets for elucidating the underlying mechanisms of neurological diseases. Understanding these kinases is fundamental to unraveling the complex pathologies of these disorders.

Fig.1 Kinase structure.¹

CNS-related Cellular Kinase Assays

Traditional biochemical assays, limited by their simplified environments, often yield unreliable results due to the absence of crucial cellular complexities like membrane barriers, cofactor distribution, and pH gradients. Our advanced cell matrix analysis overcomes these limitations, providing accurate evaluations of key indicators:

• Target Affinity and Occupancy: Quantitatively measure real-time binding within cells, ensuring precise understanding of drug-target interactions.
• Cell Selectivity and Off-Target Effects: Screen against a comprehensive panel of 192-240 full-length kinases, revealing potential toxicity and ensuring target specificity.
• Direct Action Verification of Inhibitors: Distinguish whether compounds effectively penetrate cell membranes to engage their intended targets, validating true intracellular efficacy.

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Reference

1. Benn, Caroline L., and Lee A. Dawson. "Clinically precedented protein kinases: Rationale for their use in neurodegenerative disease." Frontiers in Aging Neuroscience 12 (2020): 242. Distributed under Open Access license CC BY 4.0, without modification.