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Creative Biolabs

Neurogenesis Assay Service

Are you exploring the frontiers of neurodegenerative disease treatment? Our neurogenesis assay service provides the robust, reliable data you need to advance your research. We specialize in quantifying and characterizing neurogenesis, the critical process of new neuron formation, offering invaluable insights into potential therapies for Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and more. Our neurogenesis assay service empowers your research with cutting-edge experimental techniques and in-depth data analysis, providing comprehensive support for your neurogenesis studies. For further information regarding the products and services provided, project-specific consultation, and pricing, please submit an inquiry here.

Overview of Neurogenesis

(Creative Biolabs Original) CC BY 4.0, from Wiki, without modification. Neurogenesis, the creation of new neurons, isn't limited to embryonic development. It persists in the adult mammalian brain, including humans, primarily within the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) of the hippocampus. Neurons born in the SGZ integrate into hippocampal circuits, playing a vital role in learning and memory. Those generated in the SVZ migrate to the olfactory bulb, influencing our sense of smell. While initial research pinpointed these two regions, emerging evidence suggests neurogenesis may also occur in other brain areas, such as the cortex and thalamus, though this varies across species.

Precision Neurogenesis Analysis

(Creative Biolabs Original) High-Resolution Detection The hippocampus is an essential part of the brain that plays a key role in the processes of learning, memory formation, and navigating through space. These neurons are widely used to explore various neurodegenerative diseases, such as Alzheimer's disease, temporal lobe epilepsy, amnesia, and the dementias.
(Creative Biolabs Original) Versatile Model Support Our service accommodates a wide range of experimental models, from acute brain and spinal cord slices to iPSC-derived neurons, ensuring flexibility for diverse research objectives.
(Creative Biolabs Original) AI-Powered Data Insights Leveraging artificial intelligence-driven analysis tools, we rapidly identify complex network activity patterns and neurogenesis-related gene expression changes, accelerating your data interpretation.

Service Process

Tailored Model Selection Choose from primary neurons, iPSC-derived cells, or organoid models, customized to your specific disease model (e.g., ischemic stroke, tauopathy).
Flexible Compound Handling We support single-dose or gradient concentration testing, compatible with small molecules, antibodies, and gene therapy vectors.
Comprehensive Multimodal Analysis Utilizing immunofluorescence staining, we quantify neurofilament nodes and dendritic spine density. MEA capture essential electrophysiological characteristics, including network oscillations and burst discharges.
Actionable Data Delivery Receive standardized reports detailing IC50/EC50 values and pathway activation levels, alongside customized mechanistic interpretations to drive your research forward.

Case Study: Isolation and in vitro clonal expansion of neural stem (NS) cells from ES cells or embryonic and adult neural tissues.

Fig.1: NS cell potential of the in vitro neuroepithelial rosette cultures. Fig.1 NS cell potential of in vitro neuroepithelium rosette cultures.1

Ready to accelerate your neuroregeneration research? Contact our scientific team today to explore our services or request a complimentary sample. Let's collaborate and drive the next wave of breakthroughs in neuroregenerative therapy.

Reference

  1. Abranches, Elsa, et al. "Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo." PloS one 4.7 (2009): e6286. Distributed under Open Access license CC BY 4.0, without modification.
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