ALS Therapeutic Target Characterization Service

Creative Biolabs offers comprehensive service that encompasses an array of aspects, from identifying potential therapeutic targets to elucidating cellular processes implicated in Amyotrophic Lateral Sclerosis (ALS) pathogenesis.

Highlighted ALS Therapeutic Targets

Creative Biolabs provides an extensive array of characterization assays targeting ALS-associated genes, aiming to address diverse facets of ALS pathogenesis. The following is a compilation of gene targets currently under investigation for potential ALS therapeutic interventions:

Target Characterization Assays at Creative Biolabs

• Post-Translational Modifications Assay

Some of ALS targets undergo various post-translational modifications, including phosphorylation, ubiquitination, and cleavage.

Abnormal modifications can lead to aggregation into insoluble protein aggregates, a hallmark of ALS and FTLD pathology.

• Aggregation Assay

In ALS and FTLD, protein aggregates are commonly found in the cytoplasm of affected neurons. Aggregated proteins are often hyperphosphorylated and ubiquitinated, contributing to their misfolding and accumulation.

• Cellular Localization Assay

Proteins are normally localized in the nucleus, where they participate in RNA-related processes. In ALS disease, these proteins can translocate to the cytoplasm and form pathological aggregates. We provide nucleo-cytoplasmic transport assay and mislocalization assay to confirm the localization of specific proteins.

• RNA Binding and Processing Assay

Most ALS targets bind to RNA and regulate the splicing patterns of various genes. Dysregulation of RNA processing due to gene dysfunction can contribute to neurodegenerative processes.

• Stress Granule Formation Assay

Stress granules are cellular structures that form in response to various stressors, such as oxidative stress or cellular damage, and are implicated in ALS and other neurodegenerative diseases.

Highlighted Targets Characterization

Characterizing the proteins associated with ALS is crucial for understanding the molecular mechanisms underlying the disease. Here's a brief overview of our protein characterization for some key ALS-associated genes:

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