C. elegans High-Content Phenotypic Screening Assay

Creative Biolabs is proud to present the cutting-edge C. elegans High-Content Screening Assay, a revolutionary platform that has transformed neuroscience research. This advanced assay leverages the unique attributes of the model organism Caenorhabditis elegans (C. elegans) to provide comprehensive insights into various biological processes and disease mechanisms.

Why C. elegans?

• In-depth study of the model: The fully sequenced genome shares extensive homology with the human genome. It includes records related to diseases such as aging and neurodegenerative disorders.
• Small size and translucency: It is easy to observe GFP-labeled targets under a microscope.
• Short lifespan: Significantly reduces the experimental cycle. Experiments are conducted using the natural aging process rather than accelerated aging.
• In vivo and preclinical research: Genome editing is applicable to multicellular organisms.
• Low cost: Mainly fed with Escherichia coli. They are hermaphroditic, and the cost of reproduction and cultivation is relatively low.

How Can We Help You?

The C. elegans high-Content screening assay service developed by Creative Biolabs encompasses several key features that set it apart from traditional screening methods.

• Phenotypic Profiling

By leveraging the unique advantages of C. elegans, the assay enables comprehensive phenotypic profiling of various biological processes. Researchers can evaluate a wide range of phenotypic characteristics, including developmental abnormalities, locomotor behavior, reproductive health, and neurodegenerative changes. This holistic approach provides a more comprehensive understanding of biological phenomena and facilitates the identification of potential therapeutic targets.

• Drug Discovery and Toxicity Assessment

The C. elegans High-Content Screening Assay is a valuable tool in drug discovery and toxicity assessment. Through large-scale screening of compound libraries, researchers can identify molecules with desired effects on C. elegans physiology.

Our Test List

Creative Biolabs offers the following services for your research on the model organism Caenorhabditis elegans to fulfill your experimental objectives:

• Identification of homologous genes and conserved amino acids in Caenorhabditis elegans.
• Gene mutation/knockout.
• Analysis of phenotypes after RNAi/overexpression.
• Fluorescent protein labeling and localization.
• Phenotype assays:
  1) Fertility assessment (measuring embryo lethality, larval arrest, and brood size).
  2) Body length measurement.
  3) Lifespan determination.

Our High-Throughput Screening Workflow

Creative Biolabs has pioneered the development of a high-throughput platform specifically designed for the C. elegans High-Content Screening Assay. This innovative platform combines cutting-edge imaging technologies, advanced image analysis algorithms, and automation systems, enabling rapid and accurate screening of large populations of C. elegans.

Fig.1 C. elegans High-Throughput Screening Workflow. (Creative Biolabs)

The C. elegans High-Content Screening Assay offers a multitude of advantages, revolutionizing the field of neuroscience research. By harnessing the potential of this assay, scientists can uncover valuable insights into neuronal development, synaptic plasticity, and the pathogenesis of neurodegenerative diseases.

We are committed to providing our clients with high-quality, reliable, and cost-effective Transgenic C. elegans assay service for neurological research. Please feel free to contact us for more about our C. elegans models related services.