Cytokine Release Assay

Cytokines are involved in immune-inflammatory processes and are associated with oligodendrocyte death, axonal degeneration, and neuronal dysfunction, which are key features of multiple sclerosis (MS) pathology and underlie irreversible defects. To better study the pathogenesis of MS and find therapeutic targets, cytokine release assay (CRA) and evaluation are particularly important.

Creative Biolabs is dedicated to delivering comprehensive, high-quality data and offering timely and efficient solutions to address any challenges you may encounter in the context of MS cytokine release assays.

The Cytokine Profile in MS

In MS, an aberrant immune response triggers the release of various cytokines, leading to inflammation and tissue damage. Creative Biolabs offers cutting-edge CRA services that allow researchers to analyze the cytokine profile in MS patients. By quantifying the levels of pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), and anti-inflammatory cytokines, including interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), researchers can gain a comprehensive understanding of the immune response dynamics.

Cytokine Detection Platform

Creative Biolabs offers a cytokine detection platform and expert cytokine detection technology services to support your scientific research needs.

Our cytokine detection platform uses fluorescent microspheres coupled with highly specific capture monoclonal antibodies and then adds secondary antibodies to measure the fluorescence intensity of a single microsphere, which can effectively detect multiple cytokines at the same time. The cytokine detection platform has the following features:

• High throughput: Detect multiple indicators simultaneously.
• High efficiency: Short experimental time.
• High sensitivity: ≥0.1 pg/mL.

Creative Biolabs also provide other detection methods for CRA assay:

• Real-time quantitative polymerase chain reaction assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry
• Intracellular Cytokine Staining (ICS) Analysis

Given the mechanisms and complexity of cytokine release in neurological diseases, Creative Biolabs has developed many different formats of cytokine release assays. We have the flexibility to meet the unique needs of cytokine release assay projects.

Please do not hesitate to contact us to advance your research projects.