- NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody,Clone NR1616P (Cat#: NRZP-1022-ZP3505)
- NeuroMab™ Anti-CD32b Antibody, Clone NR130P (Cat#: NRP-0422-P1803)
- NeuroMab™ Anti-FGFR1 Antibody,Clone NR3547P (Cat#: NRP-0422-P1244)
- NeuroMab™ Anti-TNFα BBB Shuttle Antibody,Clone NR3088P (Cat#: NRZP-1022-ZP4105)
- NeuroMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- NeuroMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody,Clone NR2431P (Cat#: NRZP-1222-ZP1218)
- Tau Monoclonal Antibody (AT120, HT7 and BT2 clone) (Cat#: NK-2106-P008)
- NeuroMab™ Anti-Amyloid Beta 1-15 Antibody,Clone NR2660P (Cat#: NRP-0422-P867)
- NeuroMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- NeuroMab™ Anti-CD20 Antibody,Clone NR3021P (Cat#: NRP-0422-P1230)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- iNeu™ Human Midbrain Dopaminergic Neurons (Cat#: NCL-21P6-003)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Human Neurons Isolated from Cortex (Cat#: NCL-21P6-023)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- AAV2/9-hEF1a-fDIO-eNpHR 3.0-mCherry-WPRE-pA (Cat#: NTA-2012-ZP78)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- AAV2/9-hSyn-Flpo-EGFP-WPRE-pA (Cat#: NTA-2012-ZP149)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- Dextran-CYanine5.5 (Cat#: NTA-2011-ZP118)
- pAAV-syn-FLEX-jGCaMP8f-WPRE (Cat#: NTA-2106-P064)
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- ABCA1 Antisense Oligonucleotide (AK311445) (Cat#: NV-2106-P27)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein, cTfRMAb-GDNF (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein, cTfRMAb-EPO (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, HIRMab-TNFR (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-EPO BBB Shuttle Protein, HIRMab-EPO (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein, HIRMab-PON1 (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein, HIRMab-SGSH (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-ASA BBB Shuttle Protein, HIRMab-ASA (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein, HIRMab-IDUA (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein, HIRMab-GDNF (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein, cTfRMAb-TNFR (Cat#: NRZP-0423-ZP501)
Myelination, Demyelination and Remyelination Assay
Myelination, the process by which myelin sheaths are formed around axons in the central nervous system (CNS) and peripheral nervous system (PNS), plays a crucial role in proper neuronal function. Demyelination, on the other hand, refers to the loss or damage of these myelin sheaths. Both myelination and demyelination processes have significant implications in various neurological disorders, such as multiple sclerosis (MS). Therefore, the study of myelination, demyelination, and remyelination has gained immense importance in neuroscience research.
Creative Biolabs offers a comprehensive range of services for studying myelination, demyelination, and remyelination assays. Our team of highly skilled experts, with over 20 years of experience in the field, is dedicated to providing cutting-edge solutions to advance our understanding of these processes and develop potential therapeutics.
Assay Models
Creative Biolabs offers a range of assay models to simulate myelination, demyelination, and remyelination processes in vitro. These models include:
- Primary Cell Culture Models: Primary oligodendrocyte cultures, co-cultures of oligodendrocytes and neurons, and 3D brain organoids culture systems can be utilized to study myelination and the effects of various compounds on myelin formation and maintenance.
- Ex vivo Rodent Model: Organotypic cultures allow to perform myelination studies in a more complex and anatomically preserved environment; the slices can be isolated from transgenic mice for fate-mapping studies, demyelinated with toxicants and used to test the remyelinating potential of candidate compounds.
- Human Induced Pluripotent Stem Cell (iPSC)-Derived Models: Human iPSC-derived oligodendrocyte models provide a valuable tool for studying human-specific aspects of myelination, demyelination, and remyelination. These models allow for the assessment of patient-specific responses and the screening of potential drug candidates.
Figure 1. In vitro models to study myelination, demyelination and remyelination. (Marangon, 2021)
Workflow for Modeling Human iPSC-Derived Oligodendrocytes
Creative Biolabs has developed a robust workflow for modeling human iPSC-derived oligodendrocytes (iOligo™), enabling the investigation of myelination in a human-relevant system. This workflow includes the following steps:
Highlights
![Versatile Assay Models](static/img/myelination-demyelination-and-remyelination-assay-2.jpg)
Versatile Assay Models
We offer a range of in vitro assay models, allowing you to choose the most appropriate model for your research needs.
![Versatile Assay Models](static/img/myelination-demyelination-and-remyelination-assay-3.jpg)
Timely Delivery
We are committed to delivering results in a timely manner, allowing researchers to advance their projects efficiently.
![Customization](static/img/myelination-demyelination-and-remyelination-assay-4.jpg)
Customization
Our experienced scientists can tailor the assay protocols and models to suit your specific requirements, ensuring the best fit for your project.
![Expertise](static/img/myelination-demyelination-and-remyelination-assay-5.jpg)
Expertise
Our team of highly skilled experts possesses extensive experience in the field of neuroscience research, ensuring the highest quality of service and reliable results.
Options for Using Our iOligo™
Creative Biolabs provides flexible options for utilizing our iOligo™:
-
Order iOligo products for use in your lab
If you are interested in ordering iOligo and perform the assay in your lab, we offer a convenient and flexible supply of iOligo, along with a ready-to-use iOligo kit. -
Outsource your experiments to us
We offer a swift and dependable service that involves collaborative experiment design to address your specific inquiries, delivering results within a span of 2 months. Our tailored projects are conducted within our cutting-edge facilities.
Cat. | Product Name |
NCL-2103-P49 | iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) |
NCL-21P6-105 | Oligodendrocyte Precursor Cell Growth Medium |
NCL-21P6-106 | Oligodendrocyte Precursor Cell Differentiation Medium |
For further information or to initiate a discussion regarding your unique requirements, please contact us today to explore the possibilities of collaborating with our organization.
Reference
- Marangon, Davide, et al. "Novel in vitro experimental approaches to study myelination and remyelination in the central nervous system." Frontiers in Cellular Neuroscience 15 (2021): 748849.