Neurotransmitter Detection Assay
Background of Neurotransmitter
Neurotransmitters are generated by neurons, which play a role in signal transmission by carrying chemical messengers to target cells across synapses. There are over 100 neurotransmitters that have been already identified, including acetylcholine, oxytocin, glutamate, GABA, serotonin, dopamine, norepinephrine, etc. Maintaining appropriate homeostasis of neurotransmitters is an ideal way to prevent neurological diseases, including neurodegenerative diseases (such as Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease), depression, anxiety, neuropsychiatric diseases, and neurotraumatic diseases. Different neurotransmitters bind to their corresponding receptors. Understanding the properties, structure, function, and release of neurotransmitters enable researchers to investigate the functional mechanisms of neurotransmitters and thus contribute to the novel therapy development for various neurological diseases.
Neurotransmitter Detection Assay
For a novel therapy development purpose, Creative Biolabs provides a full range of in vitro neurotransmitter detection assays that enable researchers comprehensively study different neurotransmitters. Since the physiological processes of neurotransmitter generation, storage, and release are distributed throughout the nervous, muscular, and sensory systems and are an important part of normal physiological function in humans and animals, we collect samples including cerebrospinal fluid, microdialysates, brain tissues, plasma, urine, muscle tissues, various organs, and samples for in vitro studies. We provide radioligand receptor binding techniques (radioimmunoassay), liquid chromatography-mass spectrometry (LC-MS), and high-performance liquid chromatography (HPLC) technology combined with electrochemical or fluorescence detection, which can be used to detect neurotransmitter alterations that affect neurological processes and drug candidates. Therefore, the neurotransmitter detection assay is able to comprehensively shed light on the mechanism of action of multiple neurological diseases and screen targets of interest and promising drug candidates. We offer customized analyte services for neurotransmitters including but not limited to the following list:
| Types | Neurotransmitters |
| Amino acids | glutamate, aspartate, GABA, glycine, D-serine, etc. |
| Peptides | somatostatin, oxytocin, substance P, cocaine, opioid peptides, etc. |
| Monoamines | dopamine, norepinephrine, adrenaline, histamine, serotonin, etc. |
| Trace amines | phenethylamine, tryptamine, tyramine, 3-iodothyronamine, N-methylphenethylamine, octopamine, etc. |
| Gasotransmitters | carbon monoxide (CO), hydrogen sulfide (H2S), nitric oxide (NO), etc. |
| Purines | adenosine, adenosine triphosphate (ATP), etc. |
| Others | acetylcholine (ACh), anandamide, etc. |
Creative Biolabs provides comprehensive in vitro neurotransmitter detection assays, which enable researchers to understand the mechanism of action of multiple neurotransmitters and the mechanisms of drug candidate effects on neurotransmitters. Our services enable our global customers to develop promising drugs for neurotransmitter homeostasis. Our professional team of neurological scientists is here to support you to customize your neurotransmitter research and development project. If you want to learn more about neurotransmitter detection assays, please contact us.
