NeuroMab™ Anti-Brevican BBB Shuttle Antibody, Clone N294A/6

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Brevican BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 219-655 of rat Brevican (also known as Brevican core protein, Brainenriched hyaluronan-binding protein, BEHAB, BCAN, Chondroitin sulfate proteoglycan 7 and CSPG7, accession number P55068)
Mouse: 92% identity (403/437 amino acids identical)
Human: 75% identity (350/464 amino acids identical)
<40% identity with Aggrecan

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N294A/6

Applications

WB; IHC; ICC

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Brevican

Official Name

BCAN

Full Name

Brevican

Alternative Names

BCAN; BEHAB; CSPG7; Brevican

Uniprot ID

P55068

Product Pictures

Fig. 1 Immunoblot versus crude membrane preparations from adult rat brain (RBM) and Brevican wild-type (WT) and knockout (KO) mice and probed with N294A/6 (left) and N52A/42 (right) TC supe.

Publications