NeuroMab™ Anti-CD171 BBB Shuttle Antibody(NRZP-1022-ZP3531)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG

Applications

WB; ELISA; Inhib; In Vitro; In Vivo

Relevant Diseases

Tumor

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CD171

Official Name

L1CAM

Full Name

L1 cell adhesion molecule

Alternative Names

L1CAM; CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1; L1 cell adhesion molecule

Product Pictures

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Figure 1 is the analysis results of the inhibition of cell proliferation after the L1CAM expression antibody A10-A3 and cisplatin were administered separately or in combination with the L1CAM expression antibody A10-A3 and cisplatin, B) is the analysis result of the apoptosis induction after administration of the L1CAM antibody A10 -A3 and cisplatin against L1CAM-expressing cholangiocarcinoma cell line (SCK) individually or in combination,

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Figure 2 is a group of mice (10 mice each) treated with mIgG, L1CAM antibody A10-A3, cisplatin or A10-A3 and cisplatin in mice transplanted with an L1CAM-expressing cholangiocarcinoma cell line (SCK) ( xenograft) model. ) showing cancer growth,

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Figure 3 (A) and (B) Cholangiocarcinoma cell line (SCK) and ovarian cancer cell line (SK-OV3) expressing L1CAM, respectively, or in combination with orally administered anti-L1CAM antibody A10-A3 and gemcitabine, which was the basis for analyzing the inhibitory effect on cell proliferation result,

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Figure 4 (A) and (B) Analysis of cell proliferation inhibition in cholangiocarcinoma cell line (SCK) and ovarian cancer cell line (SK-OV3) expressing L1CAM, respectively, or after combined administration of anti-L1CAM antibody A10-A3 and 5-fluorouracil result of action,

Publications