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Creative Biolabs

NeuroMab™ Anti-CD171 BBB Shuttle Antibody(NRZP-1022-ZP3534)

[CAT#: NRZP-1022-ZP3534]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; ELISA; FC; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG

Applications

WB; ELISA; FC; In Vitro; In Vivo

Relevant Diseases

Tumor
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

CD171

Official Name

L1CAM

Full Name

L1 cell adhesion molecule

Alternative Names

L1CAM; CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1; L1 cell adhesion molecule
Product Pictures
FuncS

Figure 1: Measurement of cellular uptake of antibody L1CAM mAb OV52.24 on Skov3ip cells.

FuncS

Figure 2: Measurement of cellular uptake of L1CAM mAb 9.3 and OV52.24 on Skov3ip cells.

FuncS

Figure 3: Measurement of cellular uptake of L1CAM mAb 9.3 and OV52.24 on Skov3ip cells using confocal laser scanning microscopy.

FuncS

Figure 4: Measurement and comparison of cellular uptake of antibodies L1CAM mAb 9.3, OV52.24, 5G3 and UJ127.11 on Skov3ip cells.

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