NeuroMab™ Anti-IL-6 Antibody(NRP-0422-P1516)

Product Overview

Description

The IL-6 antibody is specific for antigenic determinants of IL-6. The affinity value determined for NRP-0422-P1516 was in the range 9.02-10.50 μM with a mean±s.e.m. of 9.76±0.74 μM.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

Inhib; Block; In Vitro; In Vivo; Neut

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Gene ID

3569(Human)

Uniprot ID

P05231(Human)

Product Pictures

Inhib

Figure 1 shows the inhibition of T1165 cell proliferation induced by human recombinant, human mammalian, rhesus monkey, rhesus monkey and mouse IL-6 by antibody 240.g1.

Inhib

Figure 2 shows the inhibition of MCP-1 production induced by human recombinant IL-6 and sIL-6R in HUVECs by antibody 240.g1.

Inhib

Figure 3 shows the inhibition of IL-17-induced endogenous IL-6 and sIL-6R-induced MCP-1 production in HU VECs by antibody 240.g1.

Neut

Figure 4 Neutralization of hIL-6-induced SAA in mice by administration of CA030_240.g1 (site 3 antibody) n=7-8/group except PBS n=6. **P<0.01 compared with IL-6 alone, statistical analysis by ANOVA with Bonferroni post hoc test.

Publications