NeuroMab™ Anti-Sortilin BBB Shuttle Antibody(NRZP-1022-ZP2775)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mammalian

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; Inhib; In Vitro; In Vivo; Antagonist

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

SORT1

Official Name

SORT1

Full Name

Sortilin

Alternative Names

SORT1; Gp95; LDLCQ6; NT3; NTR3; Sortilin 1

Product Pictures

Inhib

Figure 1 shows the dose-dependent inhibition of biotinylated progranulin binding to soltilin-expressing cells by anti-soltilin antibodies.

Inhib

Figure 2 shows cell surface expression levels of saltylin after incubation with anti-saltillin antibody for 72 hours.

Inhib

Figure 3 shows the measurement of mouse progranulin (PGRN) protein levels in mouse plasma samples at different times after injection of anti-saultyrin antibodies.