Mouse Anti-Human Fascin-1 Monoclonal Antibody (CBP4247)

[CAT#: NAB210114LS]

Anti-Fascin-1 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB

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Product Overview

Description

Fascin is a 55 kD F-actin binding protein that is involved in cell motility and migration. Fascin plays an important role in the organization and formation of membrane ruffles, stress fibers, and a diverse set of cell protrusions, such as filopodia. In the mouse subventricular zone-derived migratory neuroblasts, Fascin is highly upregulated to guide the migration of cells along the rostral migratory stream. In Drosophila, Fascin controls neuronal class-specific dendrite arbor morphology to elicit the accurate establishment of neuronal circuits.

Immunogen

Recombinant human Fascin full-length protein

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP4247

Applications

Application Notes

WB (0.2-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Fascin-1

Official Name

FSCN1

Full Name

Fascin-1

Alternative Names

FSCN1; FAN1; HSN; SNL; p55; fascin actin-bundling protein 1

Gene ID

6624

Uniprot ID

Q16658

References

1. Yamashiro S, et al. 1998. Mol Biol Cell. 9(5): 993-1006.
2. Nagel J, et al. 2012. Development 139, 2999-3009
3 .Sonego M, et al. 2013. J Neurosci. 33(30): 12171-85.

Publications