NeuroMab™ Anti-Artemin Antibody(NRP-0422-P534)

Product Overview

Description

The monoclonal antibody NRP-0422-P534 specifically binds to E. coli rat Neublastin protein. The NRP-0422-P534 monoclonal antibody was also found to bind to human neublastin. The antibody can be used for detecting the presence or amount of endogenous and/or exogenous neublastin in a sample and in methods of antagonizing neublastin bioactivity.

Immunogen

human neublastin (hNBN104)-hIgG1 Fc recombinant protein

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; ELISA; Block; Inhib; In Vitro

Relevant Diseases

Alzheimer's Disease; Parkinson's Disease; Huntington's Disease; Multiple Sclerosis

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Artemin

Official Name

artemin

Full Name

ARTN

Alternative Names

ENOVIN; Neublastin; EVN; Artemin; Enovin; NBN; ARTN;

Gene ID

9048(Human);11876(Mouse)

Uniprot ID

Q5T4W7(Human);Q9Z0L2(Mouse)

Product Pictures

Inhib

Figure 1 is a scatter plot depicting the ability of anti-hNBN mAbs to inhibit NBN-mediated c-RET phosphorylation in mouse cells.

Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).

Publications