NeuroMab™ Anti-CD126 Antibody(NRP-0422-P1520)
[CAT#: NRP-0422-P1520]
Functional antibody against Human IL-6R
- Host Species:
- Rabbit; Humanized
- Species Reactivity:
- Human
- Applications:
- FC; Inhib; Block; In Vitro; In Vivo; Neut
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
NRP-0422-P1520 had>10 fold higher inhibition of STAT3 phosphorylation as compared to tocilizumab (hPM-1).
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rabbit; Humanized
Applications
FC; Inhib; Block; In Vitro; In Vivo; Neut
Relevant Diseases
Neuroinflammation; Amyotrophic Lateral Sclerosis
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
> 95% (SDS-PAGE)
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Product Pictures
ELISA
Figure 1 Humanized lead anti-IL-6R antibody candidates retain most of the activity of their rabbit counterparts.
Direct ELISA of anti-IL-6R antibodies.
FCM
Figure 2 Humanized lead anti-IL-7R antibody candidates retain most of their rabbit antibody activity.
Anti-IL-6R antibody binding to IL-6R on human myeloma U266B1 cells measured by FACS
Block
Figure 3 Humanized lead anti-IL-8R antibody candidates retain most of the activity of their rabbit counterparts.
Ability of anti-IL-6R antibodies to block IL-6 binding to IL-6R.
FuncS
Figure 4 Humanized lead anti-IL-9R antibody candidates retain most of the activity of their rabbit counterparts.
Humanized anti-IL-6R antibodies inhibit IL-6 mediated proliferation of TF-1 cells.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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