NeuroMab™ Anti-CD4 BBB Shuttle Antibody(NRZP-1022-ZP3717)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

ELISA; FC; Inhib

Relevant Diseases

Meningitis

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CD4

Official Name

CD4

Alternative Names

CD4; CD4mut; CD4 molecule

Product Pictures

ELISA

Figure 1 shows the results of an ELISA assay in which murine and hB-F5s could moderately inhibit ConA-induced proliferation, but the activity varied by antibody and/or donor.

ELISA

Figure 2 shows the results of an ELISA assay in which murine and hB-F5 were able to inhibit Ag-specific PBMC proliferation induced by PPD.

FuncS

Figure 3 shows the inhibitory activity test, where negative control (not activated) is preCD25; 0.5 μg/ml OKT-3 (positive control, fully activated) is preCD25-CD3; 5 μg/ml hB-F5 (test 1) is preCD25- CD4; 30 μg/ml hB-F5 (Test 2) is preCD25-CD4.

Publications