NeuroMab™ Anti-EGFRvIII BBB Shuttle Antibody(NRZP-1022-ZP3910)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Isotype

IgG1

Applications

In Vivo; In Vitro

Relevant Diseases

Alzheimer's Disease; Pain; Multiple Sclerosis

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

EGFRvIII

Official Name

EGFRvIII

Full Name

Epidermal Growth Factor Receptor Variant III

Product Pictures

ELISA

Figure 1 shows the binding characteristics of H1H1863N2(Fuc−).

Figure 2 shows the internalization of anti-EGFRvIII mAb in HEK293 cells expressing EGFRvIII (HEK293/EGFRvIII).

Figure 3 shows the binding and internalization of B16F10.9 tumors or B16F10.9 tumors expressing EGFRvIII (B16F10.9/EGFRvIII) xenografted in severe combined immunodeficiency (SCID) mice by the anti-EGFRvIII antibody H1H1863N2(Fuc-) .

Figure 4 shows the binding and internalization of anti-EGFRvIII antibody H1H1863N2(Fuc-) xenografted into B16F10.9 tumors or B16F10.9 tumors expressing EGFRvIII (B16F10.9/EGFRvIII) in severe combined immunodeficiency (SCID) mice change.

FuncS

Figure 5ab(ad) shows the pharmacokinetic analysis results of anti-EGFRvIII antibody H1H863N2(Fuc+) and control antibody.

FuncS

Figure 5(cd) shows the pharmacokinetic analysis results of anti-EGFRvIII antibody H1H863N2(Fuc+) and control antibody. Namely, control I (panel b), control III (panel c) and control IV (panel a), in wild-type mice (●) or mice expressing human EGFR (▪).

Publications