NeuroMab™ Anti-Galanin BBB Shuttle Antibody(NRZP-1022-ZP3927)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Epilepsy; Depression

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Galanin

Official Name

GAL

Full Name

Galanin

Alternative Names

GAL; GAL-GMAP; GALN; GLNN; GMAP; ETL8; galanin and GMAP prepropeptide

Product Pictures

Figure 1 shows the results of the affinity assay.

Hybridoma supernatants from confluent cultures were serially diluted, preincubated with 125 I-labeled human galanin, and precipitated with an excess of protein G sepharose. Monoclonal antibodies produced by hybridomas are ranked according to affinity. The following seven mAbs were rated as high affinity: 2H9, 1G12, 5B4, 1D7, 4B3, 2F8, and 1A1. The following mAbs were rated as low affinity: 4G5, 2B11, 4C10, 1C1, 1D6, 4A10, 2F9, 5C5, and 2E11.

FuncS

Figure 2 shows that administration of anti-galanin antibodies reduces tumor growth in established tumors.

Athymic nude mice injected with 5 million COLO-677 cells were administered 200 μg of anti-galanin IgG or vehicle approximately 10-14 days after the tumor volume reached approximately 50-100 mm3.

Publications