NeuroMab™ Anti-IL-1 Beta BBB Shuttle Antibody(NRZP-1022-ZP2857)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Human

Applications

WB; In Vivo; In Vitro; Inhib

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Il-1β

Official Name

IL1B

Full Name

Interleukin 1 beta

Alternative Names

IL1B; IL-1; IL1-BETA; IL1F2; interleukin 1 beta; IL1beta

Product Pictures

ELISA

Figure 1 is a graph showing the results of a kinetic exclusion assay for an antibody designated AB7.

Inhib

Figure 2 is a graph showing the results of in vitro IL-1β stimulation experiments with AB1 and AB7 antibodies.

FuncS

Figure 4 is a histogram showing the results of in vivo stimulation experiments for antibodies designated AB5 and AB7.

Figure 5 is a Western blot showing the results of cross-reactivity experiments of antibodies designated AB7 with recombinant human, mouse and rat IL-1β.

FuncS

Figure 6 is a graph showing the results of an in vitro experiment involving the antibody designated AB7 and Kineret involving IL-1-induced IL-8 production.

Publications