NeuroMab™ Anti-IL-10 Antibody(NRP-0422-P1492)

Product Overview

Description

The monoclonal antibody is capable of binding to interleukin-10 (1L-10), and is capable of being administered to a subject in the absence of an intolerable increase in the level of pro-inflammatory cytokines.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Chimeric

Applications

ELISA; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

IL-10

Official Name

IL10

Full Name

Interleukin 10

Alternative Names

Interleukin 10

Gene ID

3586(Human)

Uniprot ID

P22301(Human)

Product Pictures

ELISA

Figure 1 provides a comparison of the antigen binding properties of humanized antibody variants with chimeric cB-N10 antibody using hIL-10 antigen ELISA.

ELISA

Figure 2 presents the results of an assay of the binding properties of the three humanized variants hVH20/hVL7, hVH20/hVL8 and hVH26/hVL7 compared to chimeric B-N10 antibodies using purified antibody preparations.

ELISA

Figure 3 shows the level of TNFalpha release in whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).

ELISA

Figure 4 shows the release levels of IL-6 from whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).

ELISA

Figure 5 shows the release levels of IL-1beta from whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).