NeuroMab™ Anti-IL-6 Antibody(NRP-0422-P1527)

Product Overview

Description

The modified NRP-0422-P1526 comprising M252Y, S254T, and T256E substitutions is referred to as NRP-0422-P1527. NRP-0422-P1526 binds to human and cynomolgus IL-6 but not to IL-6 from murine, rat, or dog. NRP-0422-P1526 binds to human IL-6 with an affinity that is higher than the 10 pM detection level of the BIAcore assay. The affinity of NRP-0422-P1526 for human IL-6 was estimated to be 0.40 pM (95% CI 0.12 pM to 0.69 pM) using the TF-1 cell proliferation assay. NRP-0422-P1526 can block IL-6 binding to IL-6R.

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; Inhib; In Vitro; In Vivo; Neut

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Gene ID

3569(Human)

Uniprot ID

P05231(Human)

Product Pictures

ELISA

Figure 1 Antibody 18E and Antibody 18 in ELISA assay.

FuncS

Figure 2 shows the serum concentrations of antibodies 18 and 18E over time following a single subcutaneous or intravenous administration of a single 5 mg/mL antibody dose.