NeuroMab™ Anti-IL-6 BBB Shuttle Antibody(NRZP-1022-ZP2906)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

In Vitro; In Vivo; Inhib; Antagonist

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Product Pictures

FuncS

Figure 1 is a graph illustrating experimental results of IVT administration of an anti-IL-6 antibody in a rat CNV model.

Anti-VEGF antibody was administered as a positive control and the negative control was vehicle alone, p = 0.0054 on Day 15 and p = 0.0005 on Day 22 for anti-IL-6 vs. vehicle control.

Inhib

Figure 2 is a graph illustrating the results of a binding experiment testing the ability of the murine 64 antibody to inhibit the binding of IL-6/IL-6R to gp130.

Inhib

Figure 3 is a graph illustrating an experiment in which the ability of 020 to block IL-6 signaling was tested in the absence of excess soluble IL-6Ra.

Experiments were performed in HEK-Blue-IL-6 cells with 0.2 ng/mL IL-6 and 2pg/mL IL6Ra.

Inhib

Figure 4 is a graph illustrating an experiment in which the ability of 020 to block IL-6 signaling was tested in the absence of excess soluble IL-6Ra.

Experiments were performed in HEK-Blue-IL-6 cells with 0.2 ng/mL IL-6 and 2pg/mL IL6Ra.

Publications