NeuroMab™ Anti-IL-6 BBB Shuttle Antibody(NRZP-1022-ZP2909)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

Inhib; Block; In Vitro; In Vivo; Neut

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Product Pictures

Inhib

Figure 1 shows the inhibition of T1165 cell proliferation induced by human recombinant, human mammalian, rhesus monkey, rhesus monkey and mouse IL-6 by antibody 240.g1.

Inhib

Figure 2 shows the inhibition of MCP-1 production induced by human recombinant IL-6 and sIL-6R in HUVECs by antibody 240.g1.

Inhib

Figure 3 shows the inhibition of IL-17-induced endogenous IL-6 and sIL-6R-induced MCP-1 production in HU VECs by antibody 240.g1.

Neut

Figure 4 Neutralization of hIL-6-induced SAA in mice by administration of CA030_240.g1 (site 3 antibody) n=7-8/group except PBS n=6. **P<0.01 compared with IL-6 alone, statistical analysis by ANOVA with Bonferroni post hoc test.

Publications