Product
NeuroMab™ Anti-NOS1/nNOS BBB Shuttle Antibody, Clone L121/42
[CAT#: NRZP-0423-ZP304]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-nNOS BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 350-720 of human NOS1 (also known as Brain nitric oxide synthase, Constitutive NOS, Neuronal NOS, Peptidyl-cysteine S-nitrosylase NOS1, NC-NOS, NOS type I, N-NOS, nNOS and BNOS, accession number P29475)
Rat: 98% identity (363/371 amino acids identical)
Mouse: 98% identity (362/370 amino acids identical)
>70% identity with NOS2/iNOS and NOS3/eNOS
Rat: 98% identity (363/371 amino acids identical)
Mouse: 98% identity (362/370 amino acids identical)
>70% identity with NOS2/iNOS and NOS3/eNOS
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
L121/42
Applications
WB; IHC; ICC
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
nNOS
Official Name
NOS1
Full Name
nNOS/NOS1
Alternative Names
NOS1; IHPS1; N-NOS; NC-NOS; NOS; bNOS; nNOS; nitric oxide synthase 1
Uniprot ID
P29475
Product Pictures
IHC
Fig. 1 Adult rat cortex immunohistochemistry.
IHC
Fig. 2 Adult rat striatum immunohistochemistry.
IHC
Fig. 3 Adult rat hippocampus immunohistochemistry.
IB
Fig. 4 Adult rat brain membrane immunoblot.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
