NeuroMab™ Anti-PSK9 Antibody(NRP-0422-P1536)
[CAT#: NRP-0422-P1536]
Functional antibody against Human PCSK9
- Host Species:
- Rabbit; Humanized
- Species Reactivity:
- Human
- Applications:
- ELISA; Block; Inhib; In Vitro; In Vivo
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The anti-PCSK9 antibody shows binding specificity for PCSK9 and blocks the interaction of PCSK9 with LDLR. The anti-PCSK9 antibody can be used for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.
Epitope
Fab
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rabbit; Humanized
Applications
ELISA; Block; Inhib; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease; Stroke; Neuroinflammation
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
> 95% (SDS-PAGE)
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Target
PSK9
Official Name
PCSK9
Full Name
Proprotein Convertase Subtilisin/Kexin Type 9
Alternative Names
Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9; NARC-1; NARC1; PC9; Convertase Subtilisin/Kexin Type 9 Preproprotein; Hypercholesterolemia; Autosomal Dominant 3; Neural Apoptosis Regulated Convertase 1; Neural Apoptosis-Regulated Convertase 1;
Gene ID
100102(Human)
Uniprot ID
Q80W65(Human)
Product Pictures
ELISA
Figure 1 provides binding data of anti-PCSK9 antibody to human PCSK9 of antibody Ab23.
Inhib
Figure 2 Inhibition of LDL uptake by antibody Ab24.
Inhib
Figure 3 Inhibition data of anti-PCSK9 antibody Ab23 blocking the interaction between PCSK9 and LDLR.
Inhib
Figure 4 presents data showing the percent change in serum LDL-C cholesterol levels in Ab23-injected cynomolgus monkeys relative to pre-dose levels.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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