NeuroMab™ Anti-TMEM106B Antibody(NRP-0422-P717)

Product Overview

Description

The antibody specifically binds to a mammalian TMEM106B or a human TMEM106B, useful for treating individuals in need of it.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; ELISA; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Parkinson's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

TMEM106B

Official Name

TMEM106B

Full Name

Transmembrane Protein 106B

Alternative Names

Transmembrane Protein 106B;

Gene ID

54664(Human); 71900(Mouse)

Uniprot ID

Q9NUM4(Human); Q80X71(Mouse)

Product Pictures

FuncS

Figure 1 presents data showing the percent downregulation of TMEM106B in A549 cells following the addition of various anti-TMEM106B antibodies.

The endpoint after 30 h was normalized to the isotype control (gray bars) and the percent aggregated TDP-43 was calculated for ACI-7069-633B12-AM (dashed gray bars). Mean ± SD of three independent experiments are shown and statistical differences between isotype control and ACI-7069-633B12-AM (IgG2a variant) were analyzed by Welch's t-test (*** p < 0.001).

Publications