Creative Biolabs

Mouse Anti-CHGA Monoclonal Antibody (AB133)

[CAT#: NAB2007FY1688]

Amyotrophic Lateral Sclerosis,
Parkinson's, Alzheimer's and Huntington's diseases

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB; IF

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Description
Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. Chromogranin A or parathyroid secreted protein 1 (gene name CHGA) is a member of the Granin family of neuroendocrine proteins, that is, it is located in the secretory vesicles of neurons and endocrine cells, such as islet β-cell secretory particles in the islets. In humans, chromogranin A protein is encoded by the CHGA gene.

Chromogranin A is a precursor of several functional peptides, including vasostatin-1, vasostatin-2, pancreatin, catestatin and parastatin. These peptides negatively regulate the neuroendocrine function of released cells (autocrine) or nearby cells (paracrine).

Chromogranin A induces and promotes the production of secretory particles, such as insulin-containing particles in pancreatic beta cells.
Epitope
Binds to an located within the peptide sequence HSGFEDELSEVLENQ
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
AB133
Applications
IHC; WB; IF
Application Notes
IHC: 1:1000-1:2500
WB: 1 µg/ml
IF: 2-10 µg/ml
Relevant Diseases
Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis
Form
Liquid
Formulation
PBS, pH 7.2, 40% glycerol
Preservatives
0.02% Sodium azide
Concentration
1 mg/ml
Purification
Protein A purified
Shipping
Gel Pack
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling Advice
The antibody solution should be gently mixed before use.
Research Use Only
For research use only
Target
Chromogranin A
Official Name
CHGA
Full Name
Chromogranin A
Alternative Names
Chromogranin A; Parathyroid Secretory Protein; Pituitary Secretory Protein I; Chromogranin-A; SP-I 3 4; Betagranin (N-Terminal Fragment Of Chromogranin A) 3; Pancreastatin 2
Gene ID
12652 (Mouse); 24258 (Rat)
Uniprot ID
P10645 (Human); P26339 (Mouse); P10354 (Rat)
Neural Antibodies
Kits
Neural Proteins & Peptides
For Research Use Only. Not For Clinical Use.
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