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![](static/images/product/product-icon-neural-antibodies.png)
NeuroMab™ Anti-Alpha Synuclein Antibody, Clone NR47P
A functional antibody raised against Human, Mouse Alpha Synuclein.
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse
- Applications:
- ELISA; WB; IP; In Vitro
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryDescription
Species Reactivity
Clonality
Host Species
Clone Number
Applications
Relevant Diseases
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
Storage
Research Use Only
Figure 1 shows the results of passive immunotherapy with antibodies on memory performance in the probe portion of the Morris water maze test.
Pepscan analysis revealed that NI-202.21D11 overlapped with peptides B08 (aa 109-123 of SEQ ID NO: 1), B09 (aa 113-127 of SEQ ID NO: 1) and B10 (aa of SEQ ID NO: 117-131) Binding to human α-synuclein of 1) shows that the minimal sequence required for NI-202.21D11 binding is PVDPDNE within human α-synuclein (aa 117-123 of SEQ ID NO: 1).
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P552-1.png)
Figure 2 shows the results of an ELISA assay testing the affinity of different humanized 5C1 antibodies.
Pepscan analysis revealed that NI-202.21D11 overlapped with peptides B08 (aa 109-123 of SEQ ID NO: 1), B09 (aa 113-127 of SEQ ID NO: 1) and B10 (aa of SEQ ID NO: 117-131) Binding to human α-synuclein of 1) shows that the minimal sequence required for NI-202.21D11 binding is PVDPDNE within human α-synuclein (aa 117-123 of SEQ ID NO: 1).
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P552-2.png)
Figure 3 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of [alpha]-synuclein to which the 5D12 antibody binds.
The upper part of the panel shows a western blot of full-length α-synuclein (wild-type or a single point mutation in residues 118-126, as indicated) stained with the 5D12 antibody.
![](https://img.creative-biolabs.com/neuros/productImages/NRP-0523-P552-3.png)
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