
NeuroMab™ Anti-Alpha Synuclein Antibody, Clone NR51P
A functional antibody raised against Human Alpha Synuclein.
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- DB; ELISA; FC; IHC; In Vitro; Cyt; In Vivo
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Species Reactivity
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Host Species
Clone Number
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Preservatives
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Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
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Research Use Only
Figure 1 α-synuclein staining in the brainstem of α-synuclein [A30P] transgenic mice.
Fresh-frozen 10 μm sagittal brain section; 40X magnification; all images under the same lighting conditions; arrows indicate Lewy neurite-like inclusions.

Figure 2 Staining of the cerebral cortex of patients with Parkinson's disease with antibodies 0017 and 0018.
(A), Alzheimer's disease patient with Parkinson's disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); Arrowhead: Lewy body-like inclusion; Arrowhead: Lewy neurite- like inclusions.

Figure 3 Cytotoxicity of conditioned medium of recombinant α-synuclein from SHSY5Y cells on LUHMES cells.
(A), Alzheimer's disease patient with Parkinson's disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); Arrowhead: Lewy body-like inclusion; Arrowhead: Lewy neurite- like inclusions.

Figure 4 The antibodies are capable of immunodepleting α-synuclein oligomers in the extracellular medium, thus these antibodies reduce the toxicity of α-synuclein oligomers.
(A), Alzheimer's disease patient with Parkinson's disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); Arrowhead: Lewy body-like inclusion; Arrowhead: Lewy neurite- like inclusions.

Figure 5 Confocal microscopy analysis of immunohistochemical cryosections of brain sections from patients with Parkinson's disease (same settings for all images).
(A) Antibody 0017, (B) Antibody 0018.
