Product
NeuroMab™ Anti-BDNF BBB Shuttle Antibody, Clone N450/53
[CAT#: NRZP-0423-ZP41]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-BDNF BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-249 (full length) of mouse BDNF (also known as Brain-derived neurotrophic factor and Abrineurin, , accession number P21237)
Rat: 99% identity (247/249 amino acids identical)
Human: 97% identity (241/249 amino acids identical)
<50% identity with Neutrophin-3 and other neurotrophic factors
Rat: 99% identity (247/249 amino acids identical)
Human: 97% identity (241/249 amino acids identical)
<50% identity with Neutrophin-3 and other neurotrophic factors
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
N450/53
Applications
WB; IHC; ICC
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
BDNF
Official Name
BDNF
Full Name
BDNF
Alternative Names
Brain Derived Neurotrophic Factor; Neurotrophin; Abrineurin; Brain-Derived Neurotrophic Factor; ANON2; BULN2;
Uniprot ID
P21237
Product Pictures
IF
Fig. 1 Immunofluorescence labeling of adult rat hippocampus with N450/53 TC supe (red) and Hoechst nuclear stain (blue).
IB
Fig. 2 Immunoblot of adult rat hippocampus with N450/53 TC supe.
Publications
Publications (0)
Neural Antibodies
Kits
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
