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Creative Biolabs

NeuroMab™ Anti-CD304 BBB Shuttle Antibody(NRZP-1022-ZP3295)

[CAT#: NRZP-1022-ZP3295]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; ELISA; IHC; In Vitro

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; ELISA; IHC; In Vitro

Relevant Diseases

Hypertensive Heart Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

CD304

Official Name

NRP1

Full Name

Neuropilin-1

Alternative Names

NRP1; BDCA4; CD304; NP1; NRP; VEGF165R; Neuropilin 1
Product Pictures
WB

Figure 1 Western blot using NRP-1 monoclonal antibody.

WB

Figure 2 Comparison of Western Blotting results

IHC

Figure 3 Epitope analysis of 15-mer synthetic peptide

IHC

Figure 4 mAb clone 4.002.023 produced monoclonal antibodies that only showed specific membrane staining on Nrpl transfected cells

IHC

Figure 5 NRP-1 as an immunogen shows good IHC staining of cells transfected with NRP-1.

IHC

Figure 6 mAb produced by mAb clone 4.002.023 showed strong membrane staining on tumor cells.

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