Mouse Anti-Human Neuropilin 1 Monoclonal Antibody (CBP2272)

Product Overview

Description

CD304 (Neuropilin 1) is a membrane receptor that plays a role in establishment of certain neuronal circuits during neurogenesis, as well as in organogenesis outside of the nervous system. CD304 binds semaphorin 3A and VEGFA. The interaction between CD304 and VEGFA initiates a signaling pathway that is needed for cell migration and axonal guidance in the motor neuron system.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP2272

Applications

Application Notes

WB (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD304

Official Name

NRP1

Full Name

Neuropilin-1

Alternative Names

NRP1; BDCA4; CD304; NP1; NRP; VEGF165R; Neuropilin 1

Gene ID

8829(Human); 18186(Mouse); 246331(Rat)

Uniprot ID

O14786(Human); P97333(Mouse); Q9QWJ9(Rat)

References

1. Niland S, Eble JA. 2019. Int. J. Mol. Sci. 20(3).
2. Gudapati P, et al. 2020. Cytometry B. Clin. Cytom. 10.1002/cyto.b.21866.
3. Ding Z, et al. 2019. Mol. Carcinog. 58:1019.

Publications