NeuroMab™ Anti-CXCL10 BBB Shuttle Antibody(NRZP-1022-ZP3435)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Isotype

IgG

Applications

WB; ELISA; IHC; Neut; Block; In Vitro; In Vivo; Antagonist

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CXCL10

Official Name

CXCL10

Full Name

chemokine (C-X-C motif) ligand 10

Alternative Names

gIP-10; INP10; 10 kDa interferon gamma-induced protein; IP-10; C-X-C motif chemokine 10; 1-73; Small-inducible cytokine B10; IFI10; Gamma-IP10; SCYB10; crg-2; C7; mob-1

Product Pictures

ELISA

Figure 1 depicts the results of a competition ELISA showing the affinity of HuAlP13 for human IP-10.

ELISA

Figure 2A depicts the binding of murine AIP 13 and AIP 12 to human recombinant IP-10. B depicts the binding of HuAIP13 and HuATP12 to recombinant human IP-10.

FuncS

Figure 3 depicts AIP12, AIP13, HuAff 12 and HuAIP13-mediated inhibition of IP-10 binding to CXCR3.

FuncS

Figure 4 depicts the inhibition of recombinant human IP-10-mediated chemotaxis by AIP12, ATP13, HuAIP12 and HuAIP13.

FuncS

Figure 5 depicts the inhibition of native human IP-10-mediated chemotaxis by AIP 12, AIP13, HuAJP12 and HuAIP13.

FuncS

Figure 6 depicts the inhibition of IP-10-mediated chemotaxis in cynomolgus monkeys by AIP12, AIP13, HuAIP12 and HuAIP13.

FuncS

Figure 7 depicts the competition of AIP 12, HuAEP12 and HuAIP13 with biotinylated AJP13.

FuncS

Figure 8 depicts the competition of AIP12, ATP13, HuAJP12 and HuAIP13 with biotinylated ATP12. Both assays indicated that HuAIP12 exhibited a higher relative affinity than HuATP13 for IP-10 binding.