NeuroMab™ Anti-CXCL10 BBB Shuttle Antibody(NRZP-1022-ZP3435)
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; IHC; Neut; Block; In Vitro; In Vivo; Antagonist
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 depicts the results of a competition ELISA showing the affinity of HuAlP13 for human IP-10.
Figure 2A depicts the binding of murine AIP 13 and AIP 12 to human recombinant IP-10. B depicts the binding of HuAIP13 and HuATP12 to recombinant human IP-10.
Figure 3 depicts AIP12, AIP13, HuAff 12 and HuAIP13-mediated inhibition of IP-10 binding to CXCR3.
Figure 4 depicts the inhibition of recombinant human IP-10-mediated chemotaxis by AIP12, ATP13, HuAIP12 and HuAIP13.
Figure 5 depicts the inhibition of native human IP-10-mediated chemotaxis by AIP 12, AIP13, HuAJP12 and HuAIP13.
Figure 6 depicts the inhibition of IP-10-mediated chemotaxis in cynomolgus monkeys by AIP12, AIP13, HuAIP12 and HuAIP13.
Figure 7 depicts the competition of AIP 12, HuAEP12 and HuAIP13 with biotinylated AJP13.
Figure 8 depicts the competition of AIP12, ATP13, HuAJP12 and HuAIP13 with biotinylated ATP12. Both assays indicated that HuAIP12 exhibited a higher relative affinity than HuATP13 for IP-10 binding.
Figure 9 depicts that the disease causes weight loss in a mouse model of IBD.
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