NeuroMab™ Anti-CXCR4 BBB Shuttle Antibody(NRZP-1022-ZP3809)
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IHC; In Vitro
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
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Figure 1 shows EasyCyte staining demonstrating binding of B-1M22, C-9P21, C-1I24, and D-1K21 scFv clones to CXCR4-transfected and non-transfected HEK293 cell lines.
Figure 2 shows EasyCyte staining of 105 Jurkat cells with 0.5 μg each of B-1M22, C-9P21, C-1I24 and D-1K21 scFv clones, without and competing ligands and AMD-3100.
Figure 3 shows the binding of B-1M22, C-9P21, C-1124 and D-1K21 to HEK293T/17 cells transiently expressing mouse or monkey CXCR4. Columns labeled "Fugene" are cells treated with transfection agent but without DNA. This column was used as a negative control.
Figure 4 shows the EasyCyte experiment in which B-1M22, C-9P21, C-1I24 and D-1K21 scFv clones were titrated on CCRF-CEM cells to determine the optimal concentration for Ca++ flux assay.
Figure 5 shows the results of the Ca++-flux assay on CCRF-CEM cells (labeled with Fluo-4).
Figure 6 shows the induction of ADCC by anti-CXCR4 antibodies B-1M22, C-9P21, C-1124 and D-1K21.
Dose-response killing of CCRF-CEM cells is shown for scFvs C-9P21 and D-1K21 (a), IgG C-9P21 and D-1K21 (b), and IgG B-1M22 and C-1I24.
Figure 7 shows the results of assays testing the ability of antibodies B-1M22, C-9P21, C-1I24 and D-1K21 to induce CDC.
Dose-response killing of Ramos cells in the presence of human serum is shown for IgG B-1M22 and C-1I24. As a control, antibody F7 in IgG1 format was used.
Figure 8 shows the analysis of apoptotic activity of anti-CXCR4 antibodies B-1M22, C-9P21, C-1124 and D-1K21 with Annexin V. As controls, antibody F7 and staurosporine (S; 25nM) were used.
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