NeuroMab™ Anti-CXCR4 BBB Shuttle Antibody(NRZP-1022-ZP3816)

Figure 1 shows that the 427aB1 Mab recognizes CXCR4 monomers and homodimers on cell lysates.

Figure 2 shows that 427aB1 Mab immunoprecipitates CXCR4 monomers and homodimers.

Figure 3A shows that 427aB1 Mab recognizes CXCR4 at the cell membrane by FACS analysis.

Figure 3B shows that 427aB1 Mab recognizes CXCR4 on the cell membrane by FACS analysis.

Figure 3C shows that 427aB1 Mab recognizes CXCR4 at the cell membrane by FACS analysis.

Figure 3D showing that 427aB1 Mab recognizes CXCR4 on the cell membrane by FACS analysis.

Figure 4A illustrates by FACS analysis that the 427aB1 Mab binds CXCR4 at the cell membrane even in the presence of the anti-CXCR4 515H7 therapeutic Mab.

Figure 4B illustrates by FACS analysis that the 427aB1 Mab binds CXCR4 at the cell membrane even in the presence of the anti-CXCR4 515H7 therapeutic Mab.

Figure 5 shows that 427aB1 Mab does not modulate CXCR4/CXCR2 heterodimer conformation.

Figure 6 shows that 427aB1 Mab has no effect on the MDA-MB-231 xenograft tumor growth model in Nod/Scid mice.