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Creative Biolabs

NeuroMab™ Anti-GFAP BBB Shuttle Antibody(NRZP-1022-ZP3932)

[CAT#: NRZP-1022-ZP3932]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; IHC; In Vitro; IF

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; IHC; In Vitro; IF

Relevant Diseases

Alzheimer's Disease; Neuroinflammation; Meningoencephalomyelitis
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

GFAP

Official Name

GFAP

Full Name

Glial Fibrillary Acidic Protein

Alternative Names

Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD;
Product Pictures
WB

Figure 1 shows that embodiment 3 identifies the Western blot detection result figure of complete GFAP (Full length GFAP, GFAP-with monoclonal antibody Umab129 FL) protein. Lane 1 is the cell lysate transfected with pCMV6-Entry; Lane 2 is the cell lysate transfected with pCMV6-GFAP-FL;

WB

Figure 2 is a Western blot detection result diagram of using the monoclonal antibody Umab129 to identify endogenous GFAP protein in SNB19 human glioblastoma cells in Example 3.

WB

Figure 3 is a diagram showing the detection results of endogenous GFAP eggs in 10 different human tissue lysates by using the monoclonal antibody Umab129 White Western blot in Example 3. From left to right: 1: testis, 2: omentum, 3: uterus, 4: breast, 5: brain, 6: liver, 7: ovary, 8: colon, 9: spleen, 10: thyroid.

WB

Figure 4 is a graph showing the results of Western blot detection of mouse brain tissue lysates identified by endogenous GFAP protein monoclonal antibody Umab129 in Example 3.

IHC

Figure 5 Immunohistochemical diagram of paraffin-embedded GFAP monoclonal antibody Umab129);

IHC

Figure 6 Paraffin-embedded immunohistochemical results (the primary antibody is GFAP monoclonal antibody Umab129);

IHC

Figure 7 shows the results of immunohistochemistry (paraffin embedding-anti-For GFAP monoclonal antibody Umab129);

IF

Figure 8 and Figure 11 show (green is the result of immunofluorescence staining of 5 rat primary neuron cells stained by the primary antibody GFAP Dank stained with the Grand antibody Umab129 in the example, and blue is DAPI staining).

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