NeuroMab™ Anti-Il-1β Antibody(NRP-0422-P1454)

Product Overview

Description

The IL-1β binding antibody shows desirable affinity and potency, such as in vitro IL-1β stimulation, in vivo IL-1β stimulation

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Human

Applications

WB; In Vivo; In Vitro; Inhib

Relevant Diseases

Neuroinflammation

Conjugation

APC; Biotin; PE; PE-Vio 615; PE-Vio 770

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Il-1β

Official Name

IL1B

Alternative Names

IL1B; IL-1; IL1-BETA; IL1F2; interleukin 1 beta; IL1beta

Gene ID

3553

Uniprot ID

P01584

Product Pictures

ELISA

Figure 1 is a graph showing the results of a kinetic exclusion assay for an antibody designated AB7.

Inhib

Figure 2 is a graph showing the results of in vitro IL-1β stimulation experiments with AB1 and AB7 antibodies.

FuncS

Figure 4 is a histogram showing the results of in vivo stimulation experiments for antibodies designated AB5 and AB7.

Figure 5 is a Western blot showing the results of cross-reactivity experiments of antibodies designated AB7 with recombinant human, mouse and rat IL-1β.

FuncS

Figure 6 is a graph showing the results of an in vitro experiment involving the antibody designated AB7 and Kineret involving IL-1-induced IL-8 production.

Publications