Mouse Anti-IL1B Monoclonal Antibody (CBP2841)

Product Overview

Description

Interleukin-1 mediates the panoply of host reactions collectively known as acute phase response. It is identical to endogenous pyrogen. The multiple biologic activities that define IL1 are properties of a 15- to 18-kD protein that is derived from a 30- to 35-kD precursor. Interleukin 1β (IL-1B) is a member of the interleukin 1 cytokine family. It is a pro-inflammatory cytokine against infection, playing an important role in the pathogenesis of cancers. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets.

Expression Host

Mammalian cells

Immunogen

IL-1 Beta fusion protein Ag26030

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2841

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Il-1β

Official Name

IL1B

Full Name

Interleukin 1, beta

Alternative Names

Catabolin; IL 1; IL 1 beta; IL1 BETA; IL-1 beta; IL1B; IL1beta; IL1F2; Interleukin 1 beta; interleukin 1; beta

Gene ID

16176(Mouse)

Uniprot ID

P10749(Mouse)

References

1. Yang, X., Yang, R., Chen, M., Zhou, Q., Zheng, Y., Lu, C.,... & Gong, J. (2020). KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats. BMJ Open Diabetes Research and Care, 8(1), e001009. 2. Wang, G., Zhou, Y., Wang, Y., Li, D., Liu, J., & Zhang, F. (2019). Age-associated dopaminergic neuron loss and midbrain glia cell phenotypic polarization. Neuroscience, 415, 89-96. 3. Lu, Z., Zhang, D., Cui, K., Fu, X., Man, J., Lu, H.,... & Li, X. (2020). Neuroprotective Action of Teriflunomide in a Mouse Model of Transient Middle Cerebral Artery Occlusion. Neuroscience, 428, 228-241.

Publications